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Vet Pathol 43:168-178 (2006)
© 2006 American College of Veterinary Pathologists

Pathogenesis of Newcastle Disease in Commercial and Specific Pathogen-free Turkeys Experimentally Infected with Isolates of Different Virulence

A. M. Piacenti, D. J. King, B. S. Seal, J. Zhang and C. C. Brown

Department of Veterinary Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA (AMP, JZ, CCB), School of Veterinary Medicine, Department of Clinics and Surgery, Universidade Federal de Minas Gerais, MG, Brazil (AMP), Southeast Poultry Research Laboratory, USDA Agricultural Research Service, Athens, GA (DJK), Poultry Microbiology Safety Research Unit, Russell Research Center, US Department of Agriculture, Agricultural Research Service, Athens, GA (BSS)

The pathogenesis of five different Newcastle disease virus (NDV) isolates representing all pathotypes was examined in commercial and specific pathogen–free (SPF) turkeys. Experimentally-infected birds were monitored clinically and euthanatized, with subsequent tissue collection, for examination by histopathology, by immunohistochemistry for the presence of NDV nucleoprotein, and by in situ hybridization for the presence of replicating virus. Clinically, the lentogenic pathotype did not cause overt clinical signs in either commercial or SPF turkeys. Mesogenic viruses caused depression in some birds. Turkeys infected with velogenic neurotropic and velogenic viscerotropic isolates showed severe depression, and neurologic signs. Histologic appearances for all strains had many similarities to lesions observed in chickens inoculated with the various isolates; that is, lesions were present predominantly in lymphoid, intestinal, and central nervous tissues. However, in general, disease among turkeys was less severe than in chickens, and turkeys could be considered a subclinical carrier for some of the isolates.

Key words: Avian paramyxovirus 1; emerging diseases; immunohistochemistry; in situ hybridization; susceptibility; veterinary virology.

Request reprints from Dr. C C Brown, Department of Veterinary Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602-7388 (USA). E-mail: corbrown{at}vet.uga.edu


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Copyright © 2006 by the American College of Veterinary Pathologists.