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Vet Pathol 43:381-383 (2006)
© 2006 American College of Veterinary Pathologists
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Listeric Meningoencephalomyelitis in a Cougar (Felis concolor): Characterization by Histopathologic, Immunohistochemical, and Molecular Methods

I. M. Langohr, J. A. Ramos-Vara, C. C. Wu and S. F. Froderman

Abstract

Listeria monocytogenes has been recognized as an important food-borne pathogen in animals. Records of the disease caused by this bacterium in large felids are, however, rare. The nervous form of listeriosis was diagnosed in a 12-year-old male cougar (Felis concolor) with a several-day history of neurologic disease characterized by excess salivation, head pressing, and circling that progressed to recumbency and death. Microscopically, the main alteration in the brain and spinal cord was a variably severe meningoencephalomyelitis composed mainly of mononuclear cell aggregates with fewer neutrophils. L. monocytogenes was isolated from the brain by microbiological culture, and L. monocytogenes antigen was detected in formalin-fixed, paraffin-embedded sections of brain and spinal cord by immunohistochemical analysis. On the basis of the nucleotide sequence of the 16S rRNA gene, the isolated strain was determined to be serotype 1/2a. Food-borne transmission of the bacterium was suspected, but food was not available for testing.

Key words: Cougars (Felis concolor); immunohistochemistry; Listeria monocytogenes; 16S rRNA gene sequence; pathology.

Request reprints from Dr. I. M. Langohr, Animal Disease Diagnostic Laboratory, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907–2065 (USA). E-mail: ilangohr{at}purdue.edu






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