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Vet Pathol 43:560-564 (2006)
© 2006 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Malignant Mixed Müllerian Tumor in a Rabbit (Oryctolagus cuniculus): Case Report with Immunohistochemistry

M. Goto, Y. Nomura, Y. Une and M. H. Goldschmidt

Abstract

A rabbit (Oryctolagus cuniculus) with a homologous malignant mixed müllerian tumor (MMMT) of the uterus with decidualization in the sarcomatous components is described. On histologic examination, the neoplasm was characterized by a carcinomatous and a sarcomatous component with invasion of the myometrium. The epithelial component was a well-differentiated carcinoma, and the nonepithelial component contained large amounts of intracytoplasmic glycogen. The changes in stromal cells were morphologically similar to changes usually found in decidual cells in the pregnant uterus or in deciduosarcomas in rabbits. Results of immunohistochemical analysis indicated that the epithelial components stained positive with cytokeratin (CK7, AE1/3) and the decidual-stromal cells stained positive for vimentin, but did not stain with {alpha}-SMA, actin, and desmin. This case fulfills all the criteria of an MMMT in having a carcinomatous and a sarcomatous component, but differs from cases of MMMT in women in that the sarcomatous component had decidualized. To the authors' knowledge, this is the first report of a malignant mixed müllerian tumor in rabbits.

Key words: Decidual; malignant mixed müllerian tumor; rabbit; uterus.

Request reprints from Midori Goto, Laboratory of Veterinary Pathology, School of Veterinary Medicine, Azabu University 1-17-71 Fuchinobe Sagamihara, Kanagawa 229-8501 (Japan). E-mail: usalove52{at}hotmail.com




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M. G. Asakawa, M. H. Goldschmidt, Y. Une, and Y. Nomura
The Immunohistochemical Evaluation of Estrogen Receptor-{alpha} and Progesterone Receptors of Normal, Hyperplastic, and Neoplastic Endometrium in 88 Pet Rabbits
Vet. Pathol., March 1, 2008; 45(2): 217 - 225.
[Abstract] [Full Text] [PDF]


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