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Avian Riboflavin Deficiency: An Acquired Tomaculous Neuropathy

Abstract

The finding of tomacula, focal areas of sausage-shaped hypermyelination in peripheral nerves, is reported for the first time in avian riboflavin deficiency. Day-old, meat-type chickens were fed a riboflavin-deficient diet (1.8 mg/kg) and were killed on postnatal days 6, 11, 16, and 21, while control chickens were fed a conventional diet containing 5.0 mg/kg riboflavin. Tomacula were found in sciatic and brachial nerves from day 11 onward, became more frequent and prominent with increasing time, and preceded the onset of segmental demyelination.

Key words: Avian; peripheral nerve; riboflavin deficiency; tomacula.

Request reprints from Professor Peter C Blumbergs, Hanson Institute Centre for Neurological Diseases, Institute of Medical and Veterinary Science, Adelaide, South Australia 5000, (Australia)

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				Z. Cai, P. C. Blumbergs, J. W. Finnie, J. Manavis, and P. D. Thompson Selective Vulnerability of Peripheral Nerves in Avian Riboflavin Deficiency Demyelinating Polyneuropathy Vet. Pathol., January 1, 2009; 46(1): 88 - 96. [Abstract] [Full Text] [PDF]