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Vet Pathol 43:789-792 (2006)
© 2006 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Chromosome Instability in a Calf with Amelia of Thoracic Limbs

I. Szczerbal, T. Stefaniak, A. Dubiel, J. Siembieda, W. Nizanski and M. Switonski

Abstract

We report here on a case of a Holstein-Friesian male calf with the congenital total absence of thoracic limbs (amelia). Cytogenetic study showed a high rate of chromosome instability, represented by chromosome or chromatid breaks and gaps in 46% of the analyzed metaphase spreads. Moreover, 12% of the spreads appeared to be polypolid. The number of micronuclei also was significantly higher when compared to control animals. This paper discusses the association between chromosome instability and limb malformation.

Key words: Amelia; cattle; chromosome instability; congenital disorder; limb malformation; micronuclei.

Prof.Dr. M Switonski, Department of Genetics and Animal Breeding, August Cieszkowski Agricultural University of Poznan, Wolynska 33, 60-637 Poznan, Poland. E-mail: switonsk{at}jay.au.poznan.pl






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