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Reproduction of Severe Gastroesophageal Ulcers (GEU) in Gnotobiotic Swine Infected with Porcine Helicobacter pylori-like Bacteria

Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH (SK), and Department of Veterinary Microbiology, Western College of Veterinary Medicine, The University of Saskatchewan, Saskatoon, SK, Canada (JE)

Groups of gnotobiotic piglets were orally inoculated at 3 days of age with either Helicobacter heilmannii (Hh) or a newly described porcine-origin gastric Helicobacter pylori (Hp)-like bacterium. Three Hh-infected and 6 porcine Hp-like–infected swine were fed a milk replacement diet containing 5–10% (v/v) sterile corn syrup as a dietary source of fermentable carbohydrate. None of the piglets infected with Hh and supplemented with corn syrup developed gastric mucosal ulcers; 2 developed small erosive lesions in the pars esophagea. In contrast, all 6 dietary carbohydrate-supplemented Hp-like–infected swine developed severe gastroesophageal ulcers; 1 of these ex-sanguinated into the stomach and died before the end of the experiment. Four of these 6 piglets had grossly evident partially digested blood in the intestinal lumens, indicative of bleeding into the gastrointestinal tract from the stomach. These data suggest that a high carbohydrate diet and gastric colonization by porcine Hp-like bacteria facilitate development of clinically significant gastroesophageal ulcers.

Key words: Gnotobiology; helicobacters; swine; ulcers.

S KrakowkaDVMPhD, Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210 (USA)