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Vet Pathol 44:1-14 (2007)
© 2007 American College of Veterinary Pathologists
review article

Genetic Alterations in Thyroid Cancer: The Role of Mouse Models

K. A. B. Knostman, S. M. Jhiang and C. C. Capen

Departments of Veterinary Biosciences (KABK, CCC) and Physiology and Cell Biology (SMJ), The Ohio State University, Columbus, OH

Thyroid carcinomas are the most common endocrine neoplasms in humans, with a globally increasing incidence. Thyroid follicular cells and neuroendocrine (parafollicular) C cells are each susceptible to neoplastic transformation, resulting in thyroid cancers of differing phenotypes with unique associated genetic mutations and clinical outcomes. Over the past 15 years, several sophisticated genetically engineered mouse models of thyroid cancer have been created to further our understanding of the genetic events leading to thyroid carcinogenesis in vivo. The most significant mouse models of papillary, follicular, anaplastic, and medullary thyroid carcinoma are highlighted, with particular emphasis on the relationship between the relevant oncogenes in these models and genetic events in the naturally occurring human disease. Limitations of each model are presented, and the need for additional models to better recapitulate certain aspects of the human disease is discussed.

Key words: endocrine; mice; Neoplasm; thyroid.

Request reprints from Dr. Charles C Capen, Department of Veterinary Biosciences, Ohio State University, 1925 Coffey Road, Columbus, Ohio 43210. E-mail: capen.2{at}osu.edu




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[Abstract] [Full Text] [PDF]


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