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Vet Pathol 44:116-118 (2007)
© 2007 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

In vivo Endothelial Cell Infection by Anaplasma marginale

A. D. Carreño, A. R. Alleman, A. F. Barbet, G. H. Palmer, S. M. Noh and C. M. Johnson

Department of Pathobiology, Auburn University, Auburn, AL (ADC, CMJ), Department of Pathobiology, University of Florida, Gainesville, FL (ARA, AFB), and Department of Microbiology and Pathology, Washington State University, Pullman, WA (GHP, SMN)

Abstract

Anaplasma marginale has recently been shown to infect endothelial cells in vitro, but it remains unknown as to whether endothelial infection also occurs in vivo. In this report, we demonstrate through dual fluorescence microscopy that A marginale, detected by the monoclonal antibody ANAF16C1, co-localizes with the endothelial cell marker, von Willebrand factor, in tissue sections from an experimentally inoculated calf. The results indicate that A marginale infection includes endothelial cells and has implications for both pathogenesis and immune mechanisms.

Key words: Anaplasma marginale; CTL; endothelial cells; fluorescent microscopy.

Request reprints from Dr. Calvin M Johnson, Department of Pathobiology, 166 Greene Hall, College of Veterinary Medicine, Auburn University, AL 36849-5519. E-mail: johncal{at}auburn.edu




This article has been cited by other articles:


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 J. Clin. Microbiol.Home page
H. L. Wamsley and A. F. Barbet
In Situ Detection of Anaplasma spp. by DNA Target-Primed Rolling-Circle Amplification of a Padlock Probe and Intracellular Colocalization with Immunofluorescently Labeled Host Cell von Willebrand Factor
J. Clin. Microbiol., July 1, 2008; 46(7): 2314 - 2319.
[Abstract] [Full Text] [PDF]


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