Vet Pathol Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (1)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Garner, M. M.
Right arrow Articles by Kiupel, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Garner, M. M.
Right arrow Articles by Kiupel, M.
Vet Pathol 44:25-38 (2007)
© 2007 American College of Veterinary Pathologists

Myofasciitis in the Domestic Ferret

M. M. Garner1,, K. Ramsell2, N. J. Schoemaker3, I. F. Sidor4, R. W. Nordhausen5, S. Bolin7, J. F. Evermann6 and M. Kiupel7

1 Northwest ZooPath, Monroe, WA (MMG), 2 Southwest Animal Hospital, Beaverton OR (KR), 3 Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, The Netherlands (NJS), 4 Department of Pathobiology and Veterinary Science, University of Connecticut, Storrs, CT (IFS), 5 Electron Microscopy Laboratory, California Animal Health and Food Safety Laboratory, School of Veterinary Medicine, University of California, Davis, Davis, CA (RWN), 6 Washington Animal Disease Diagnostic Laboratory, Washington State University, Pullman, WA (JFE), 7 Michigan State University, Department of Pathobiology and Diagnostic Investigations, and Diagnostic Center for Population and Animal Health, Lansing, MI (SB, MK)

Since late 2003, an inflammatory disease of muscle and fascia has been diagnosed in several ferrets at Northwest ZooPath, and this report describes the condition in 17 ferrets. It is a disease of young ferrets, characterized by rapid onset of clinical signs, high fever, neutrophilic leukocytosis, treatment failure, and death (or euthanasia). Gross lesions include atrophy of skeletal muscle; red and white mottling and dilatation of the esophagus; and splenomegaly. Histologically, moderate to severe suppurative to pyogranulomatous inflammation is in the skeletal muscle and the fascia at multiple sites, including esophagus, heart, limbs, body wall, head, and lumbar regions. Myeloid hyperplasia of spleen and/or bone marrow also is a prominent feature. Ultrastructural lesions include mitochondrial swelling, intracellular edema, disruption of myofibrils and Z bands. Bacterial and viral cultures, electron microscopy, immunohistochemistry, and polymerase chain reaction were negative for a variety of infectious agents. The clinical presentation and distribution of lesions suggests that polymyositis in domestic ferrets is likely a distinct entity. The etiopathogenesis if this condition is not known.

Key words: Electron microscopy; ferrets; histopathology; immunohistochemistry; myofasciitis; PCR; polymyositis.

Request reprints from Dr. Michael Garner, 654 West Main, Monroe, WA 98272. E-mail: zoopath{at}aol.com




This article has been cited by other articles:


Home page
 Vet PatholHome page
M. M. Garner, K. Ramsell, N. Morera, C. Juan-Salles, J. Jimenez, M. Ardiaca, A. Montesinos, J. P. Teifke, C. V. Lohr, J. F. Evermann, et al.
Clinicopathologic Features of a Systemic Coronavirus-Associated Disease Resembling Feline Infectious Peritonitis in the Domestic Ferret (Mustela putorius)
Vet. Pathol., March 1, 2008; 45(2): 236 - 246.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2007 by the American College of Veterinary Pathologists.