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Three Equine Cases of Mixed Hepatoblastoma with Teratoid Features

Livestock Disease Diagnostic Center, University of Kentucky, Lexington, KY

Abstract

Hepatoblastoma was diagnosed in 3 Thoroughbreds at the University of Kentucky Livestock Disease Diagnostic Center (LDDC) since 1997. Case #1 involved a fetus with a well-demarcated, multilobulated, solitary mass that extended from the left liver lobe. Case #2 was observed in a neonate with a primary hepatic mass and multiple metastases in the skin, brain, meninges, and stylohyoid bone. Case #3 was a solitary hepatic mass incidentally discovered in a neonate at necropsy. Microscopically, the masses were similarly composed of sheets and cords of fetal and embryonal epithelial cells that frequently formed sinusoid-like structures. Intermixed with the neoplastic epithelial cells were variable amounts of hemorrhage, necrosis, osteoid, and bone. Immunohistochemically, the epithelial cells stained variably positive for alpha- fetoprotein, frequently positive for vimentin, and occasionally positive for cytokeratin. All 3 cases were diagnosed as mixed hepatoblastoma with teratoid features.

Key words: Equine; fetus; Hepatoblastoma; metastases; mixed; neonate; teratoid.

Request reprints from Dr. Alan Loynachan, Liverstock Disease Diagnostic Center, University of Kentucky, PO Box 14125, Lexington, KY 40512 (USA). E-mail: alan.loynachan{at}uky.edu