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Vet Pathol 44:225-228 (2007)
© 2007 American College of Veterinary Pathologists
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Confocal Laser Scanning Analysis of an Equine Oral Mast Cell Tumor with Atypical Expression of Tyrosine Kinase Receptor C-KIT

F. Seeliger, O. Heß, M. Pröbsting, S. Kleinschmidt, T. Woehrmann, P. G. Germann and W. Baumgärtner

Department of Pathology (SK, WB, FS), Department of Physiological Chemistry (MP), University of Veterinary Medicine Hannover, Hannover, Germany; Clinic for Equine Medicine (OH), Ulrich Mengeler, Hamminkeln, Germany; Institute for Preclinical Safety, ALTANA Pharma AG (PGG, FS, TW),, Hamburg, Germany

Abstract

A 20-year-old female horse showed a nodular, firm, focal ulcerated mast cell tumor at the right dorsobuccal face of the tongue. Histologically, the nonencapsulated tumor consisted of dense, infiltrating aggregates of well-differentiated, Cresyl violet-positive mast cells accompanied by numerous eosinophils. Furthermore, they exhibited a strong, diffuse, intracytoplasmatic immunohistochemical signal for tryptase and a faint membrane-associated and perinuclear signal for tyrosine kinase receptor KIT. Confocal laser scanning microscopy confirmed an aberrant spatial colocalization of KIT in the Golgi apparatus, which may be the result of a defective protein processing within the tumor cells. The tumor was not associated with a poor prognosis.

Key words: Confocal laser scanning microscopy; equine; KIT; mast cell tumor; tongue.

Request reprints from Dr. Frank Seeliger, ALTANA Pharma AG, Institute for Preclinical Safety, Haidkrugsweg 1, D-22885 Barsbüttel (Germany). E-mail: frank.seeliger{at}altanapharma.com






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