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Vet Pathol 44:229-232 (2007)
© 2007 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Round Cell Variant of Myxoid Liposarcoma in a Japanese Macaque (Macaca fuscata)

H.-J Kwon, M.-S Park, D. Y. Kim, D.-Y Cho, B.-I Yoon, N.-S Shin and D.-Y. Kim

Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Seoul, Korea

Abstract

A 5-year-old, female, Japanese Macaque (Macaca fuscata) was diagnosed with round cell variant of myxoid liposarcoma. At necropsy, multifocal to coalescing, reddish tan to white nodules, ranging from 0.5 to 1 cm in diameter, were noted throughout the omentum and retroperitoneum. Similar neoplastic nodules were also present in diaphragm, abdominal wall, and on hepatic capsule. Microscopically, neoplastic masses consisted of round to polyhedral cells, which had round, often eccentric nuclei and abundant eosinophilic granular and microvacuolated cytoplasm; Oil red O staining demonstrated large numbers of lipid droplets in the cytoplasm. Ultrastructurally, the cytoplasm of the tumor cells was packed with occasional lipid vacuoles and numerous enlarged mitochondria. Immunohistochemistry revealed tumor cells were positive for vimentin, while negative to cytokeratin, actin, and Factor VIII–related antigen. To the authors' knowledge, this is the first report of round-cell variant of myxoid liposarcoma in nonhuman primate.

Key words: Electron microscopy; immunohistochemistry; nonhuman primate; round-cell variant of myxoid liposarcoma.

Request reprints from D.-Y. Kim, Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, San 56-1, Shillim-dong, Kwanak-gu, Seoul 151-742 (Korea). E-mail: daeyong{at}snu.ac.kr






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Copyright © 2007 by the American College of Veterinary Pathologists.