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Vet Pathol 44:233-236 (2007)
© 2007 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Amyloid-Producing Odontogenic Tumor and Its Immunohistochemical Characterization in a Shih Tzu Dog

Y.-C Tsai, C.-R Jeng, Y.-X Zhuo, Y.-C Tsai, C.-H Liu and V. F. Pang

Graduate Institute of Veterinary Medicine, College of Bio-Resources and Agriculture, National Taiwan University, Taipei, Taiwan, ROC

Abstract

A 10-year-old, male, Shih-Tzu dog presented with swelling of the right lower jaw caused by a mass arising from the right mandibular gingiva. Radiographic examination revealed bone lysis of the right wing of the mandible. Histopathologically, the growth was characterized by indistinctly lobulated nests, islands, and strands of proliferating odontogenic and squamous epithelial cells, intermingled in close association with large numbers of irregular extracellular deposits of amyloid and amorphous calcified substance. Immunohistochemically, both epithelial components stained strongly positive for cytokeratin (AE1/AE3); the squamous epithelial cells also reacted strongly with neuron-specific enolase (NSE) and S-100 protein, whereas the odontogenic epithelial cells displayed weak immunoreactivity to NSE and partial reactivity to S-100 protein. The amyloid deposits were AE1/AE3-negative. The growth was diagnosed as an amyloid-producing odontogenic tumor.

Key words: Amyloid; dog; histochemistry; immunohistochemistry; odontogenic tumor.

Request reprints from V F.Pang, DVM, PhD, Graduate Institute of Veterinary Medicine, College of Bio-Resources and Agriculture, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 106, Taiwan (Republic of China). E-mail: pang{at}ntu.edu.tw






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Copyright © 2007 by the American College of Veterinary Pathologists.