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Vet Pathol 44:389-391 (2007)
© 2007 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Immunoglobulin Crystals in Reactive Plasma Cells in a Dog

B. Zimmerman, M. I. Yamaguchi and L. J. Rush

Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio

Abstract

Intracellular crystalline deposits of immunoglobulin are occasionally seen in human B-cell lymphoproliferative disorders such as multiple myeloma, chronic lymphocytic leukemia, and various forms of lymphoma. Even more uncommon is the occurrence of immunoglobulin crystals in benign plasma cells or reactive lymphocytes. Here we describe the histologic, immunohistochemical, and ultrastructural features of intracellular immunoglobulin crystals in nonneoplastic plasma cells in a chronic inflammatory lesion in a dog. Microscopically, the intracellular, nonbirefringent eosinophilic crystals were square to rectangular, 2–20 µm long, and caused nuclear displacement to the periphery. The crystal-containing cells, as well as some of the crystals themselves, were positive for lambda light chain. Ultrastructural findings were consistent with a lattice network of protein–molecule alignment. The cause and significance of the crystals is unknown.

Key words: Canine; cytoplasmic inclusions; electron microscopy; immunoglobulin crystals; immunohistochemistry; plasma cells.

Request reprints from Dr. L. J. Rush, Department of Veterinary Biosciences, The Ohio State University, Room 470 VMAB, 1900 Coffey Road, Columbus, OH 43210 (USA). E-mail: rush.61{at}osu.edu






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Copyright © 2007 by the American College of Veterinary Pathologists.