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Vet Pathol 44:394-397 (2007)
© 2007 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Interstitial Cell Tumor and Sertoli Cell Tumor in the Testis of a Cat

M. A. Miller, S. E. Hartnett and J. A. Ramos-Vara

Animal Disease Diagnostic Laboratory and Department of Veterinary Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette, IN (MAM, JAR); and Gilmer Park Animal Clinic, South Bend, IN (SEH)

Abstract

Testicular tumors are rarely reported in cats. We describe a case of interstitial cell tumor and Sertoli cell tumor in a cat that developed aggressive behavior and inappropriate urination 7 years after it was obtained from a shelter as an allegedly castrated 2 year old. At physical examination, the urine odor and the presence of penile papillae implied testosterone production. Testes were not palpable, but the left testis was found in the scrotum by surgical exploration and was mostly replaced by the 2 tumors. The interstitial cell tumor, but not the Sertoli cell tumor, was immunohistochemically positive for Melan-A, consistent with steroid production. Behavior improved after excision of the testis and penile papillae began to regress, but the cat was euthanatized 31/2 months after castration at the owner's request. Neither tumor had metastasized. The right testis was never found and was presumed to have been removed during the reported castration procedure.

Key words: Cat; immunohistochemistry; interstitial cell tumor; Leydig cell tumor; Melan-A; Sertoli cell tumor; testis.

M A MillerDVMPhD, Purdue University, Animal Disease Diagnostic Laboratory, 406 S. University Street, West Lafayette, IN 47907 (USA). E-mail: pegmiller{at}purdue.edu






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