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Vet Pathol 44:407-410 (2007)
© 2007 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Atrioventricular Valvular Angiectasis in Sprague-Dawley Rats

H. Fang, P. C. Howroyd, A. M. Fletcher, R. W. Diters, J. Woicke, V. G. Sasseville, C. L. Bregman, W. J. Freebern, S. K. Durham and M. G. Mense

Departments of Pathology (HF, AMF, RWD, JW, VGS, CLB, MGM) and Immunotoxicology (WJF), Drug Safety Evaluation, Pharmaceutical Research Institute, Bristol-Myers Squibb Co., Syracuse, NY; MDS Pharma Services, Les Oncins, France (PCH); Preclinical Services, Charles River Laboratories, Sparks, NV (SKD)

Abstract

Subendothelial heart valve angiectasis has been reported in cows, dogs, pigs, rats, mice, and in human fetuses and newborns. We observed a high incidence (62 in 208 animals examined) of spontaneous angiectasis on the atrioventricular (AV) valves in 10- to 40-week-old Sprague-Dawley rats. The angiectasis was observed predominately on the septal cusp of the right AV valve and located near the AV ostium in 57 of 62 animals. Of the remaining 5 valvular angiectases, 2 were present on the parietal cusp of the right AV valve and 3 were on the left AV valve. The angiectases were single or multiple, ranging from 40 to 300 µm in diameter and were characterized by light microscopy as blood-filled dilatations lined by endothelium. Spontaneously occurring abnormalities in normal laboratory animals, such as the spontaneous valvular angiectasis reported here, need to be differentiated from drug-related lesions.

Key words: Angiectasis; atrioventricular valves; hematocyst; Sprague-Dawley rats.

H Fang, Department of Pathology, Drug Safety Evaluation, Pharmaceutical Research Institute, Bristol-Myers Squibb Company, PO Box 4755, Syracuse, NY 13221-4755, (USA). E-mail: hengsheng.fang{at}bms.com






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Copyright © 2007 by the American College of Veterinary Pathologists.