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Hermaphroditism in a Sprague-Dawley Rat

Bristol-Myers Squibb Company, Syracuse, NY (RWD, HF, SKD, MGM); and Experimental Pathology Laboratories, Inc., Herndon, VA (KAF)

Abstract

A spontaneous case of unilateral true hermaphroditism was observed during the routine necropsy of a 9-week-old presumed female Sprague-Dawley rat on a repeat-dose toxicity study. There were no drug-related effects observed. True hermaphroditism is rare in rats, and despite the large numbers of rats examined annually, few cases are reported in the literature.

Key words: Hermaphrodite; ovotestis; Sprague-Dawley rat.

R W Diters, Bristol-Myers Squibb Company, PO Box 4755, Syracuse, NY 13221 (USA). E-mail: richard.diters{at}bms.com

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