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Vet Pathol 44:508-512 (2007)
© 2007 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Simultaneous Canine Distemper Virus, Canine Adenovirus Type 2, and Mycoplasma Cynos Infection in a Dog with Pneumonia

S. Chvala, V. Benetka, K. Möstl, F. Zeugswetter, J. Spergser and H. Weissenböck

Department of Pathobiology, Institute of Pathology and Forensic Veterinary Medicine (SC, HW), Institute of Bacteriology, Mycology and Hygiene (JS), Clinical Department of Diagnostic Imaging, Infectious Diseases and Clinical Pathology, Clinical Virology (VB, KM), Clinical Department of Small Animals and Horses, Clinic for Internal Medicine and Infectious Diseases (FZ), University of Veterinary Medicine, Vienna, Austria

Abstract

The present case is the first description of a triple infection with canine distemper virus (CDV), canine adenovirus (CAV) type 2, and Mycoplasma cynos in a dog. The 5-month-old female Miniature Pinscher was euthanized because of dyspnea, croaking lung sounds, weight loss, and lymphopenia. Pathologic examination revealed a fibrinous necrotizing pneumonia with large amphophilic intranuclear and acidophilic intracytoplasmatic inclusion bodies in different lung cells. Immunohistochemically, CDV antigen was present in lung and many other organs. In situ hybridization for detection of CAV nucleic acid showed positive signals in the lung only. Polymerase chain reaction of lung tissue and consecutive sequencing of the amplification product identified CAV type 2. Bacteriologic examination of lung tissue yielded large amounts of M cynos. This infection was confirmed by immunohistochemistry detecting abundant positive signals in the lung tissue.

Key words: Canine adenovirus type 2; canine distemper virus; dog; histopathology; lung; Mycoplasma cynos; pneumonia; pulmonary disease.

Request reprints from H. Weissenböck, Department of Pathobiology, Institute of Pathology and Forensic Veterinary Medicine, University of Veterinary Medicine, Veterinärplatz 1, A-1210 Vienna (Austria). E-mail: herbert.weissenboeck{at}vu&-wien.ac.at






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Copyright © 2007 by the American College of Veterinary Pathologists.