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Vet Pathol 44:513-517 (2007)
© 2007 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Testicular Interstitial Cell Tumor and Gynecomastia in a Rabbit

K. A. Maratea, J. A. Ramos-Vara, L. A. Corriveau and M. A. Miller

Animal Disease Diagnostic Laboratory (KAM, JAR, MAM), Department of Comparative Pathobiology (KAM, JAR, MAM) and Veterinary Medical Teaching Hospital (LAC), School of Veterinary Medicine, Purdue University, West Lafayette, IN

Abstract

Unilateral testicular interstitial (Leydig) cell tumor and gynecomastia were diagnosed in an adult male rabbit. The interstitial cell tumor was a well-circumscribed, 2-mm diameter, pale tan nodule composed of a uniform population of polygonal cells. Neoplastic interstitial cells exhibited diffuse, granular cytoplasmic staining with Melan A, a marker of steroid-producing cells in humans and dogs. Multiple subcutaneous masses in the caudal abdomen were associated with enlarged nipples and consisted of hyperplastic mammary gland tissue with proliferation of ducts and alveoli, marked lobule formation, and pseudolactational hyperplasia. Many epithelial cells lining the hyperplastic ducts and alveoli exhibited intense nuclear expression of progesterone receptor antigen, whereas myoepithelial cells showed strong nuclear staining for p63 antigen. This is the first report of concurrent interstitial cell tumor and gynecomastia in a rabbit and also the first description of gynecomastia in this species.

Key words: Gynecomastia; immunohistochemistry; Leydig cell tumor; mammary glands; rabbits; testis.

Request reprints from K. A. Maratea, Purdue University School of Veterinary Medicine, Comparative Pathology, 726 Harrison Street, West Lafayette, IN, 47907 (USA). E-mail: maratea{at}purdue.edu




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A. R. Irizarry-Rovira, A. M. Lennox, and J. A. Ramos-Vara
Granular Cell Tumor in the Testis of a Rabbit: Cytologic, Histologic, Immunohistochemical, and Electron Microscopic Characterization
Vet. Pathol., January 1, 2008; 45(1): 73 - 77.
[Abstract] [Full Text] [PDF]


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