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Vet Pathol 44:525-527 (2007)
© 2007 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Mammary Carcinoma with Sebaceous Differentiation in a Dog

S.-C Chang, J.-W Liao, M.-L Wong, Y.-S Lai and C.-I Liu

Department of Veterinary Medicine (S-CC, M-LW), Veterinary Medical Teaching Hospital (S-CC), and Graduate Institute of Veterinary Pathology (J-WL, C-IL), College of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan; and Department of Pathology, Hospital and Medical College of Chung Shan Medical University, Taichung, Taiwan (Y-SL)

Abstract

This report describes an invasive mammary carcinoma with a rare distinctive feature characterized by sebaceous differentiation of tumor cells. This tumor occurred in a 10-year-old female mixed breed dog. The patient had two masses in the left fifth mammary gland. Grossly, the masses were firm, whitish to light brown, and superficially ulcerated. On cut surface, they were multilobulated with foci of necrosis. Microscopically, the tumors were composed of two distinctive neoplastic components, intraductal papillary adenocarcinoma and sebaceous carcinoma. The regions of sebaceous tumor were clumped separately, contained well-developed sebaceous cells and keratinized epithelial cells, and were surrounded by few to several layers of basaloid cells. The cells with abundant foamy cytoplasm that resembled sebaceous cells were also found within the intraductal papillary-like nests of mammary carcinoma, providing evidence of sebaceous metaplasia. Sebaceous differentiation in a mammary gland tumor is possible, because skin appendages and ductal apparatus of the mammary gland share a common anlagen. This tumor had an aggressive behavior with lymphatic metastasis. Consequentially, the dog had a poor prognosis.

Key words: Canine; mammary carcinoma; sebaceous carcinoma; sebaceous metaplasia.

Request reprints from C.-I. Liu, Graduate Institute of Veterinary Pathology, College of Veterinary Medicine, National Chung-Hsing University, 250 Kuo Kuang Road, Taichung 402 (Taiwan). E-mail: ciliu{at}dragon.nchu.edu.tw






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