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Vet Pathol 44:528-532 (2007)
© 2007 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Intramedullary Cavernous Malformation of the Spinal Cord in Two Dogs

E. MacKillop, N. J. Olby, K. E. Linder and T. T. Brown

Department of Clinical Sciences (EM, NJO) and Department of Population Health and Pathobiology (KEL, TTB), North Carolina State University College of Veterinary Medicine

Abstract

Intramedullary cavernous malformations (CVMs) of the spinal cord were diagnosed in 2 adult dogs that presented for paraparesis. An intramedullary spinal cord lesion was identified on a myelogram in the first dog, and expansion of the vertebral canal was evident on radiographs in the second. Extensive intraparenchymal hemorrhage was found on gross postmortem examination in both dogs, and a distinct lobulated intramedullary mass was evident in the second dog. Microscopically, both lesions were composed of dilated, thin-walled vascular channels with little-to-no intervening neural parenchyma. Both dogs had evidence of channel thrombosis along with perilesional hemorrhage and hemosiderin accumulation. The second dog had additional degenerative changes, including thickened fibrous channel walls with hyalinization, foci of mineralization, and occasional tongues of entrapped gliotic neuropil. CVMs appear to be an uncommon cause of both acute and chronic spinal cord disease in the dog.

Key words: Cavernous hemangioma; hemorrhage; spinal cord; vascular malformation.

Request reprints from Dr. N. Olby, North Carolina State University College of Veterinary Medicine, 4700 Hillsborough Street, Raleigh, NC 27606-1428 (USA). E-mail: natasha_olby{at}ncsu.edu






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