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Vet Pathol 44:536-539 (2007)
© 2007 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Canine Adenovirus Type 1 Infection of a Eurasian River Otter (Lutra lutra)

N. Y. Park, M. C. Lee, N. V. Kurkure and H. S. Cho

Department of Veterinary Pathology, College of Veterinary Medicine, Chonnam National University (NYP, NVK, HSC); and Department of Pathology, Chonnam National University Medical School and Research Institute of Medical Science (MCL), Gwangju, Republic of Korea

Abstract

A 10-year-old female Eurasian river otter (Lutra lutra) died after prolonged anorexia and weight loss in the Seoul Grand Park Zoo, Seoul, Republic of Korea. On necropsy, the liver was found to be swollen and friable with 1 lobe enlarged and necrotic. The other organs showed no significant alterations except for mild atrophy of the right kidney. Microscopically, there was multifocal hepatic necrosis. The hepatocytes around the necrotic areas were swollen and contained large basophilic intranuclear inclusions. Periportal infiltration by plasma cells and lymphocytes was also evident. Transmission electron microscopy revealed characteristic hexagonal virus particles sized approximately 70 nm in diameter in the nuclei of the hepatocytes, which were consistent with an adenovirus. Polymerase chain reaction of the formalin-fixed, paraffin-embedded liver sections was used to determine whether the virus was either the canine adenovirus type 1 (CAV-1), canine adenovirus type 2 (CAV-2), or some other viral agent. The results of these tests showed that the virus was CAV-1. To our knowledge, this is the first report on a CAV-1 infection in an otter.

Key words: Canine adenovirus type 1; Eurasian river otter (Lutra lutra); hepatic inclusion bodies; transmission electron microscopy.

Request reprints from H. S. Cho, Department of Veterinary Pathology, College of Veterinary Medicine, Chonnam National University, Gwangju 500-757, Republic of Korea. E-mail: chsdvm{at}netsgo.com






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