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Vet Pathol 44:676-682 (2007)
© 2007 American College of Veterinary Pathologists
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Immunohistochemical Characterization and Evaluation of Prognostic Factors in Canine Oral Melanomas with Osteocartilaginous Differentiation

J. Sánchez, G. A. Ramirez, A. J. Buendia, M. Vilafranca, C. M. Martinez, J. Altimira and J. A. Navarro

Departamento de Histologia y Anatomia Patologica Veterinaria, Facultad de Veterinaria. Universidad de Murcia, Spain (JS, AJB, CMM, JAN), and Laboratorios HIstovet, San Quirze del Valles, Barcelona, Spain (GAB, MV, JA)

Abstract

Melanomas are the most common malignant oral neoplasm in dogs. Osteocartilaginous differentiation in oral melanomas is a rare feature described both in veterinary and human medicine. Here, 10 cases of this type of neoplasm were used to study their immunohistochemical, biological, and clinical characteristics. Reactivity for S100 and melan A antigen was evaluated, and 4 prognosis factors (mitotic index, invasiveness of epithelium, nuclear atypia, and proliferation index) were analyzed and correlated with the clinical course of the neoplasms after diagnosis. Immunohistochemical analysis of the studied neoplasms, including the osteocartilaginous areas, showed positive immunoreaction for S100 and melan A, except in one dog, which was negative for melan A. Analysis of the results showed that oral melamonas with osteocartilaginous differentiation have a clinical course similar to that of other melanomas in the oral cavity. Analysis of the mitotic index and the expression of proliferation marker Ki-67 could be useful tools for predicting the biological behavior of these neoplasms.

Key words: Canine; immunohistochemistry; malignant melanoma; osteocartilaginous differentiation; prognostic factor.

Request reprints from Dr. J Sánchez, Departamento de Anatomía y Anatomía Patológica Comparadas, Facultad de Veterinaria, Universidad de Murcia, 30100 Murcia (Spain). E-mail: jsanchez{at}um.es






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