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Spontaneous Osteosarcoma in a Rabbit ( Oryctolagus cuniculus)

Laboratory of Veterinary Pathology (H Kondo, HM, MI, MO, HS, TS) and Laboratory of Veterinary Internal Medicine (H Koie) College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa and Aoyama Animal Hospital Koshigaya, Saitama (MM), Japan

Abstract

A 6-year-old male cross-breed rabbit ( Oryctolagus cuniculus) was presented with lameness and severe swelling from the right shoulder to brachium. On 16-detector helical computed tomography images of the amputated right forelimb after being fixed in formalin, evident proliferative and destructive lesions of bone were observed. On histologic examination, the tumor was composed of proliferating neoplastic cells that resembled histiocytes, with abundant osteoid production. A large number of multinucleated giant cells were found throughout. This case was diagnosed as osteosarcoma by clinical, radiographic, and histologic findings. This is a rare case report of osteosarcoma in a rabbit consistent with canine predilection sites.

Key words: Computed tomography; histology; immunohistochemistry; osteosarcoma; rabbits ( Oryctolagus cuniculus).

Request reprints from Dr. Tsuneo Sato, Laboratory of Veterinary Pathology, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa (Japan). E-mail: t-sato{at}brs.nihon-u.ac.jp