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Vet Pathol 44:713-716 (2007)
© 2007 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Internal Hydrocephalus and Associated Periventricular Encephalitis in a Young Fox

M. T. Mandara, S. Pavone and G. Vitellozzi

Department of Biopathological Science and Hygiene of Food and Animal Productions, Faculty of Veterinary Medicine, University of Perugia, Perugia, Italy

Abstract

Marked lateral ventricular enlargement associated with atrophic cerebral cortex and periventricular encephalitis is described in a 2-month-old fox affected by disorientation, generalized ataxia, difficulty in walking, circling, and blindness. Clinical conditions progressed to stupor and spontaneous death within a few days. At necropsy, severe inflammatory and necrotizing lesions were observed in periventricular sites associated with diverticula and cleft formation in perithalamic areas and rhinencephalic cortex. Immunolabeling for Toxoplasma gondii, Neospora caninum, Encephalitozoon cuniculi, canine distemper virus, and rabies virus was negative. Given the presence of periventricular and choroidal neutrophilic/mononuclear cell infiltration, it is thought that a bacterial infection may have been the cause of the inflammatory lesions, with internal hydrocephalus secondary to the severe periventricular lesions. A similar condition has been previously reported in the pathogenesis of spontaneously occurring acquired canine hydrocephalus, but no viral or bacterial causes have been investigated to date.

Key words: Foxes; hydrocephalus; periventricular encephalitis.

Request reprints from Dr. M T Mandara, Department of Biopathological Science and Hygiene of Food and Animal Productions, Faculty of Veterinary Medicine, Via San Costanzo n.4, 06126 Perugia (Italy). E-mail: mandara{at}unipg.it






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