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Vet Pathol 44:842-848 (2007)
© 2007 American College of Veterinary Pathologists

Mammary Invasive Micropapillary Carcinoma in Cats: Clinicopathologic Features and Nuclear DNA Content

F. Seixas, C. Palmeira, M. A. Pires and C. Lopes

Veterinary Sciences Department, Centre of Animal and Veterinary Sciences, University of Trás-os-Montes e Alto Douro, Vila Real, Portugal (FS, MAP), Immunology Department, Portuguese Institute of Oncology, and Pathology Department, Fernando Pessoa University, Porto, Portugal (CP), Molecular Pathology and Immunology Department, Instituto de Ciências Biomédicas de Abel Salazar, University of Porto, and Pathology Department, Portuguese Institute of Oncology, Porto, Portugal (CL)

Invasive micropapillary carcinoma (IMC) is a variant of infiltrating ductal carcinoma of the breast associated with poor outcome. In this study, we report 16 carcinomas of the feline mammary gland displaying histologic features that correspond to IMC of the breast in women. The clinicopathologic findings, overall survival time, disease-free survival time, and nuclear DNA content of these cats were compared with 65 more common invasive mammary carcinomas (other feline mammary carcinoma [FMC]) of nonspecified type. IMC was associated with larger tumor size, higher histologic grade (P < .0001), deeper muscle invasion (P = .004), and more frequent lymphovascular invasion and nodal metastases (P = .009 and P = .001, respectively) than other FMCs. The aneuploid pattern was more frequent in IMC lesions. IMCs were also associated with lower survival rates. In summary, all cases of feline IMC were associated with clinicopathologic features of high biologic aggressiveness and should be classified as independent histologic types of FMC.

Key words: Cats; DNA image content; histologic types of neoplasms; invasive micropapillary carcinomas; mammary neoplasms.

Request reprints from Dr. Fernanda Seixas Travassos, Laboratório de Histologia e Anatomia Patológica, Clínicas Veterinárias, UTAD, 5001-801 Vila Real (Portugal). E-mail: fseixas{at}utad.pt






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Copyright © 2007 by the American College of Veterinary Pathologists.