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Granulomatous and Eosinophilic Rhinitis in a Cow Caused by Pseudallescheria boydii Species Complex (Anamorph Scedosporium apiospermum)

Departments of Veterinary Pathobiology (KS, JWR), and Veterinary Clinical Sciences (MJB, RNS); Oklahoma State University, Centre for Veterinary Health Sciences, Stillwater, OK; Oklahoma Animal Disease Diagnostic Laboratory, Stillwater, OK (RDW), Covance Laboratories Inc., Madison, WI (WAM)

Abstract

A 2-year-old Hereford cow was presented to the teaching hospital for increased respiratory noise and bilateral bloody nasal discharge. A nodular rhinitis was detected clinically, and the nasal biopsy revealed a granulomatous and eosinophilic rhinitis with intralesional fungi. The cow was euthanized due to financial constraints. Grossly multifocal-to-coalescing, raised, ulcerated firm nodules were present in both nares. Histologically, the lamina propria was expanded by intense infiltrates of eosinophils, epithelioid macrophages, multinucleate giant cells, lymphocytes, and plasma cells. Associated with the inflammatory cells were variably sized, septate hyphae, 5–8 µm in diameter, admixed with numerous, terminal conidia, 6–30 µm in diameter, with a discrete outer wall identified by culture as Pseudallescheria boydii species complex (anamorph Scedosporium apiospermum). The infection was localized to the nasal cavity with no gross or microscopic evidence of a systemic dissemination.

Key words: Bovine; granulomatous rhinitis; histology; mycological culture; nasal cavity; Pseudallescheria boydii species complex; Scedosporium apiospermum.

Request reprints from K. Singh, Department of Veterinary Pathobiology, McElroy Hall 250, Oklahoma State University, Stillwater, OK 74078-2007, USA. E-mail: kuldeep.singh{at}okstate.edu

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