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Vet Pathol 44:921-923 (2007)
© 2007 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Pulmonary Lymphomatoid Granulomatosis in a Dog: Evidence of Immunophenotypic Diversity and Relationship to Human Pulmonary Lymphomatoid Granulomatosis and Pulmonary Hodgkin's Disease

H.-M Park, D.-N Hwang, B.-T Kang, D.-I Jung, G.-S Song, S.-J Lee, J.-Y Yhee, C.-H Yu, A. R. Doster and J.-H Sur

Department of Veterinary Internal Medicine (H-MP, B-TK, D-IJ), Department of Veterinary Pathobiology, Small Animal Tumor Diagnostic Center (D-NH, G-SS, S-JL, J-YY, C-HY, J-HS), College of Veterinary Medicine, Konkuk University, Kwangjin-Ku, Seoul, Korea, and Department of Veterinary and Biomedical Sciences, University of Nebraska—Lincoln, Lincoln, Nebraska (ARD)

Abstract

We describe a 10-month-old, intact female American Cocker Spaniel with pulmonary lymphomatoid granulomatosis (PLG). On clinical examination, this dog presented with nonproductive dry cough, serous nasal discharge, dyspnea, and lack of appetite. Radiography showed a consolidated lesion in the left cranial lung lobe. Histopathologic examination showed a mixed population of atypical lymphoid cells that had infiltrated into the pulmonary blood vessels angiocentrically. The lymphocytes were CD3 positive, consistent with a pan-T-cell phenotype. The lymphoid cells in the lesion were also positive for CD20cy and CD79a, indicative of the presence of B cells. We also observed large Reed-Sternberg–like cells that were positive for CD15 and CD30, similar to observations in human pulmonary Hodgkin's disease (PHD). In conclusion, canine PLG in this Cocker Spaniel was associated with B and T cells, which is first identified in a case of canine PLG. It was histopathologically similar to human lymphomatoid granulomatosis and immunophenotypically similar to human PHD.

Key words: Dogs; immunohistochemistry; pulmonary Hodgkin's disease; pulmonary lymphomatoid granulomatosis.

Request reprints from Jung-Hyang Sur, DVM, PhD, Associate Professor, Department of Veterinary Pathobiology, College of Veterinary Medicine, Hwayang-dong 1, Kwangjin-Ku, Seoul 143-701, (Korea). E-mail: jsur{at}konkuk.ac.kr


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[Abstract] [Full Text] [PDF]


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