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Vet Pathol 45:63-66 (2008)
© 2008 American College of Veterinary Pathologists
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Extraventricular Neurocytoma of the Spinal Cord in a Dog

M. Huisinga, M. Henrich, K. Frese, E. Burkhardt, K. Kuchelmeister, M. Schmidt and M. Reinacher

Institut für Veterinär-Pathologie, Universität Giessen, Germany (MH, MH, KF, EB, MR), Institut für Neuropathologie, Universität Giessen, Germany (KK), and Klinik für Kleintiere—Chirurgie, Universität Giessen, Germany (MS)

Abstract

Central neurocytoma is a rare, prognostically favorable neuronal tumor of the human central nervous system, typically located intraventricularly near the foramen of Monro. Extraventricular cerebral neurocytomas and spinal tumors have also been reported. To date, however, neurocytomas have not been documented in domestic animal species. In this report, we describe a spinal cord tumor in a dog. The microscopic examination revealed tumor cells forming loosely packed clusters in some areas and palisades in other areas. In addition, they showed fine fibrillary neuropil-like areas of different sizes, sometimes resembling the "rosettes" of pineocytomas, as well as ependymoma-like perivascular pseudorosettes. The tumor cells had scant eosinophilic cytoplasm, with perinuclear halos, closely resembling the appearance of oligodendroglioma. Immunohistochemical staining showed expression of synaptophysin and neuron-specific enolase by tumor cells and pronounced in fibrillary areas. On the basis of histomorphology and immunohistochemical reactivity, the present tumor was diagnosed as extraventricular neurocytoma.

Key words: Dog; immunohistochemistry; neurocytoma; spinal cord; tumor.

Maike Huisinga, Institut für Veterinär-Pathologie der Justus-Liebig-Universität Giessen, Frankfurter Strasse 96, 35392 Giessen, (Germany). E-mail: maike.huisinga{at}vetmed.uni-giessen.de






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