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Transthyretin Amyloidosis and Two Other Aging-Related Amyloidoses in an Aged Vervet Monkey

The Corporation for Production and Research of Laboratory Primates, Tsukuba, Ibaraki, Japan (SN, SO, FO, KF), Tsukuba Primate Research Center, National Institute of Biomedical Innovation, Tsukuba, Ibaraki, Japan (NA, TS, KT), and the Department of Veterinary Medicine, College of Bioscience, Nihon University, Fujisawa, Kanagawa, Japan (HK)

Abstract

An aged male vervet monkey showed severe cardiac arrhythmia for more than 3 years. A multifocal amyloid consisting of transthyretin was deposited in all areas of the heart wall, especially in the extracellular stroma among muscle fibers and external tunica of arterioles. Moreover, the amyloid was deposited in the stroma and arterioles of other systemic organs except the liver and spleen. These characteristics are consistent with senile systemic amyloidosis in humans. A second amyloid consisting of amyloid β protein was in senile plaques and cerebral amyloid angiopathy in the cerebral cortex. A third amyloid consisting of islet amyloid polypeptide was deposited in islets of the pancreas. Apolipoprotein E and amyloid P component colocalized with the 3 amyloids. Thus, 3 different aging-related amyloids were found in an aged vervet monkey. In particular, to our knowledge, this is the first report on spontaneous transthyretin amyloidosis in animals.

Key words: Amyloidosis; amyloid β protein; IAPP; transthyretin.

Shinichiro Nakamura, Research Center for Animal Medical Science, Shiga University of Medical Science, Seta-Tsukinowa-Cho, Ohtsu, Shiga 520-2192 (Japan). E-mail: snakamur{at}belle.shiga-med.ac.jp

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