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Vet Pathol 45:77-79 (2008)
© 2008 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Choriocarcinoma with Metastasis in a Rabbit (Oryctolagus cuniculi)

M. Kaufmann-Bart and I. Fischer

Abstract

A 3-year-old female rabbit (Oryctolagus cuniculi) presented with apathy and indisposition for 2–3 days. Palpation revealed a mass in the caudal abdomen, namely, in the wall of the uterus. Ovariohysterectomy was performed, and the tissues were submitted for histopathologic examination. The mass consisted of 3 different (trophoblastic, syncytiotrophoblastic, and cytotrophoblastic) neoplastic cell types originating from the uterus. Immunohistochemistry was positive for cytokeratin in all 3 neoplastic cell types, and the syncytiotrophoblasts were positive also for human chorionic gonadotropin. Together these features allow the diagnosis choriocarcinoma. This report documents the first case of a spontaneous choriocarcinoma in a rabbit.

Key words: Choriocarcinoma; metastasis; rabbits; uterus.

Madeleine Kaufman-Bart, Institute of Veterinary Pathology, Vetsuisse Faculty Zurich, Winterthurerstrasse 268, CH-8057 Zurich (Switzerland). E-mail: mbart{at}access.unizh.ch


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