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Vet Pathol 45:181-187 (2008)
© 2008 American College of Veterinary Pathologists
DIAGNOSTIC PATHOLOGY

Nasal and Paranasal Adenocarcinomas with Neuroendocrine Differentiation in Dogs

F. Ninomiya, S. Suzuki, H. Tanaka, S. Hayashi, K. Ozaki and I. Narama

Drug Safety Research Laboratory, Taiho Pharmaceutical Co., Ltd., Tokushima, Japan (FN, SS, HT, SH), and Department of Pathology, Faculty of Pharmaceutical Science, Setsunan University, Osaka, Japan (KO, IN)

Abstract

Tumors of the nasal cavity or paranasal sinuses of 18 dogs were examined histopathologically, immunohistochemically, and histochemically. The tumors were classified histologically as 13 adenocarcinomas, 3 transitional carcinomas, 1 squamous cell carcinoma, and 1 adenosquamous carcinoma. Tumor cells were strongly immunoreactive for broad-spectrum cytokeratins in all cases, for cytokeratin 8/18 in 16 cases, and for cytokeratin 19 in 17 cases. None of the 18 carcinomas had cytologic or histologic features indicative of neuroendocrine differentiation, yet tumor cells in 5 of the 13 adenocarcinomas were argyrophilic and immunohistochemically positive for synaptophysin and chromogranin A. Results of this study indicate that neuroendocrine markers may be detected immunohistochemically and histochemically in canine nasal or paranasal adenocarcinomas despite the lack of typical histologic features of neuroendocrine differentiation.

Key words: Adenocarcinoma; dogs; immunohistochemistry; nasal cavity; neuroendocrine differentiation; paranasal sinuses.

Request reprints from Dr. F. Ninomiya, Taiho Pharmaceutical Co., Ltd., Drug Safety Research Lab, 224-2, Ebisuno, Hiraishi, Kawauchi-cho, Tokushima 771-0194 (Japan). E-mail: f-ninomiya{at}taiho.co.jp






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