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Vet Pathol 45:191-196 (2008)
© 2008 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Concurrent Peste des Petits Ruminants Virus and Pestivirus Infection in Stillborn Twin Lambs

O. Kul, N. Kabakci, A. Özkul, H. Kalender and H. T. Atmaca

Department of Pathology, Kirikkale University, Faculty of Veterinary Medicine, Yahsihan, Kirikkale, Turkey (OK, NK, HTA), Department of Virology, Ankara University, Faculty of Veterinary Medicine, Diskapi, Ankara, Turkey (AO), Department of Gynecology and Theriogenology, Kirikkale University, Faculty of Veterinary Medicine, Yahsihan, Kirikkale, Turkey (HK)

Abstract

Concurrent infection with peste des petits ruminants virus (PPRV) and pestivirus was diagnosed in stillborn twin lambs. With the flock history, the findings of epidermal syncytial cells and necrotizing bronchitis/bronchiolitis prompted testing for PPRV infection, and PPRV antigen was detected by immunohistochemistry (IHC) in the skin, lungs, kidneys, rumen, and thymus. Macroscopic anomalies that were typical of border disease included scoliosis, brachygnathism, prognathism, arthrogryposis, hydranencephaly, cerebellar hypoplasia, and hairy fleece; pestiviral antigen was detected by IHC in the brain, liver, lungs, and kidneys. Tissues from both lambs were positive by reverse transcriptase-polymerase chain reaction (RT-PCR) for PPRV and pestivirus. To the authors' knowledge, PPR has not been reported previously as a congenital infection or in combination with pestiviral infection.

Key words: Border disease; congenital infection; immunohistochemistry; lambs; peste des petits ruminants; pestivirus; polymerase chain reaction.

Request reprints from Dr. O. Kul, Kirikkale University, Faculty of Veterinary Medicine, Department of Pathology, 71451, Yahsihan, Kirikkale, (Turkey). E-mail: oguzkul72{at}yahoo.com






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