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Vet Pathol 45:207-211 (2008)
© 2008 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Xanthogranulomatous Inflammation of the Small Bowel in a Dog

M. Romanucci, D. Malatesta, P. Guardiani, P. Frescura and L. Della Salda

Department of Comparative Biomedical Sciences, Faculty of Veterinary Medicine, University of Teramo, Italy (PG,1 PF,1)

Abstract

A case of xanthogranulomatous inflammation of the small bowel in a 12-year-old male American Staffordshire Terrier is described. Disseminated yellow-white nodules 2 to 3 mm in diameter bulging on the serosal surface of the small bowel, as well as on mesenteric tissue, were detected. Histopathologic examination revealed a nodular collection of foamy cells, mainly involving serosal and muscular layers, associated with necrotic areas, hemorrhages, neovascularization, variable numbers of reactive spindle cells, neutrophils, lymphocytes, plasma cells, and rare multinucleated giant cells. Transmural lymphangectasia and mucosal lymphoplasmacytic inflammation were also observed. Both Oil Red O stain and ultrastructural study revealed lipid droplets in the cytoplasm of foamy cells. Lysozyme immunoreactivity was detected in single as well as in clustered foamy cells, while smooth muscle actin was positive in spindle cells and scattered foamy elements. Lymphangectasia associated with lymphoplasmacytic enteritis suggests a component of lymphatic fluid stasis in the pathogenesis of such lesions.

Key words: Dogs; intestinal lymphangectasia; small bowel; xanthogranulomatous inflammation.

Request reprints from Dr. L Della Salda, Department of Comparative Biomedical Sciences, Faculty of Veterinary Medicine, University of Teramo, Piazza Aldo Moro 45, 64100 Teramo (Italy). E-mail: ldellasalda{at}unite.it




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