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Vet Pathol 45:347-351 (2008)
© 2008 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Noncongophilic Fibrillary Glomerulonephritis in a Cat

P. Cavana, M. T. Capucchio, A. Bovero, D. Ripanti, D. Catalano, F. E. Scaglione, J. Miller, T. Blunden and A. M. Farca

Department of Animal Pathology, Faculty of Veterinary Medicine, University of Turin, Grugliasco (Torino), Italy (PC, MTC, DC, FES, AMF), Veterinary Clinic Valsusa, Avigliana, Turin, Italy (AB, DR), and Animal Health Trust, Diagnostic Laboratory Service, Newmarket, Suffolk, UK (JM, TB)

Abstract

This report describes an uncommon case of nonamyloidotic fibrillary glomerulonephritis. A 5-year-old female European cat was presented with nephrotic syndrome. Serum biochemistry and urinalysis revealed a mild increase in cholesterol, low total protein, severe hypoalbuminemia, and high proteinuria with a high protein-to-creatinine ratio. An histologic examination revealed an interstitial nephritis and a diffuse glomerulonephritis, with multifocal thickening of the Bowman's capsule. Transmission electron microscopy showed widespread fibrillary deposits in the glomerular basement membrane and in the mesangium. These fibrils ranged between 18 and 26 nm in diameter and were Congo red negative, which allowed their differentiation from amyloid. Immunohistochemistry demonstrated expression for immunoglobulin M (IgM) and immunoglobulin G (IgG) within the mesangium. Renal deposits of Congo red–negative amyloid-like fibrils have been described in humans, horses, monkeys, and dogs. This is the first report of noncongophilic fibrillary glomerulopathy in a cat.

Key words: Cats; fibrils; histology; immunohistochemistry; kidney; nonamyloidotic deposits; ultrastructure.

Anna Maria Farca, Dipartimento di Patologia Animale, Via Leonardo da Vinci 44, 10095 Grugliasco (Italy). E-mail: anna.farca{at}unito.it






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