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Vet Pathol 45:361-364 (2008)
© 2008 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Primary Intimal Aortic Angiosarcoma in a Dog

R. S. Ranck, K. E. Linder, M. D. Haber and D. J. Meuten

Departments of Population Health and Pathobiology (RSR, KEL, DJM), and Clinical Sciences (MDH), North Carolina State University College of Veterinary Medicine, Raleigh, NC

Abstract

A primary intimal aortic angiosarcoma was diagnosed in a 4-year-old, spayed female German Shepherd that presented for complications of thromboembolic disease because of infarcts in multiple organs. On gross examination, aneurysmal dilatation of the aorta was associated with a friable, necrotic mass attached to the endothelial surface, which partially occluded the aortic lumen. On histologic examination, plump neoplastic spindle cells formed a plaque-like mass arising from the intima that merged with a large accumulation of fibrin and necrotic debris, and projected into the lumen. Neoplastic cells invaded periaortic vessels and were seen in some infarct-associated thromboemboli. Tumor cells expressed vimentin and CD31, with infrequent, patchy staining with factor VIII-related antigen; tumor cells were negative for cytokeratin and smooth-muscle actin. Aortic angiosarcoma is a rare malignancy in humans. This is the first description of a primary intimal aortic angiosarcoma in a dog, with immunohistochemical evidence of endothelial origin.

Key words: Aneurysm; angiosarcoma; aorta; canines; CD31; immunohistochemistry; thromboembolism.

Request reprints from Dr. Keith Linder, Department of Population Health and Pathobiology, North Carolina State University College of Veterinary Medicine, 4700 Hillsborough Street, Raleigh, NC 27606 (USA). E-mail: keith_linder{at}ncsu.edu






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