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Vet Pathol 45:375-378 (2008)
© 2008 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Non-gestational Malignant Placental Site Trophoblastic Tumor of the Ovary in a 4-Year-Old Rhesus Monkey

E. Marbaix, S. Defrère, K. Ho Minh Duc, J.-C Lousse and J.-P Dehoux

Pathology Unit (EM, HMD), Gynecology Unit (SD, JCL), and Experimental Surgery Unit (JPD), Université Catholique de Louvain, Avenue Hippocrate, 56, B-1200, Brussels, Belgium

Abstract

We report a case of ovarian malignant intermediate-type trophoblastic tumor in a clinically normal, nonpregnant 4-year-old rhesus monkey (Macaca mulatta). A large solid lobulated mass replaced the right ovary and filled the pelvis. Multiple metastases were observed within the lungs and the liver. The tumor was histologically identified as predominantly composed of intermediate trophoblastic cells, without prominent hemorrhages and the classic bilaminar pattern of cyto- and syncytiotrophoblastic cells characteristic of choriocarcinoma. Immunohistochemical analysis showed the presence of placental lactogen hormone in many tumor cells and chorionic gonadotropin in a few multinucleated cells consistent with syncytiotrophoblastic differentiation. No other germ cell differentiation was identified in the pelvis mass nor in the metastases. In the absence of previous and present pregnancy, this neoplasm has to be considered as a nongestational malignant placental site trophoblastic tumor of the ovary.

Key words: Choriocarcinoma; immunohistochemistry; placental site trophoblastic tumor; primate; rhesus monkeys.

Request reprints from Dr. J.-P. Dehoux, Experimental Surgery Unit, Université Catholique de Louvain, Avenue Hippocrate, 56, B-1200, Brussels (Belgium). E-mail: jean-paul.dehoux{at}uclouvain.be


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