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Vet Pathol 45:412-416 (2008)
© 2008 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Neuronal Migration Defect: A Case of Subcortical Heterotopia in a California Sea Lion

B. Blankenship, C. Dold, E. Jensen, C. Smith, W. Van Bonn and S. Ridgway

United States Navy Marine Mammal Program, San Diego, CA

Abstract

A 2 and a half-year-old male California sea lion (Zalophus californianus) presented with a history of intermittent generalized seizures. Magnetic resonance imaging revealed a large focal mass occupying the right cerebral hemisphere with moderate dilatation of the contralateral lateral ventricle. At necropsy, the right cerebral hemispheric white matter was expanded by numerous irregularly shaped, pale pink nodules up to 10 mm in diameter. The overlying cortex was characterized by increased numbers of small, poorly developed gyri with shallow, often indistinct, sulci (polymicrogyria). Microscopically, nodules were composed of neurons, oligodendroglia, microglia, and supporting neuropil and were well delineated from the surrounding white matter. The gross, histological, and immunohistochemical features of this lesion are consistent with a neuronal migration defect resulting in unilateral subcortical heterotopia.

Key words: California sea lions; central nervous system; malformation; neuronal migration defect; nodular heterotopia; subcortical heterotopia; Zalophus californianus.

Request reprints from Dr. Brad Blankenship, 1700 Oakridge Court, Stoughton, WI 53589 (USA). E-mail: brad.blankenship{at}charter.net


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