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Vet Pathol 45:489-494 (2008)
© 2008 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Renal Collecting Duct Carcinoma in a Dog

N. Kobayashi, K. Suzuki, H. Shibuya, T. Sato, I. Aoki and Y. Nagashima

Department of Molecular Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan (NK, IA, YN), and Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Kanagawa, Japan (NK, KS, HS, TS)

Abstract

An 8-year-old, male, mongrel dog developed severe cough and anorexia and died within 3 months. Autopsy revealed an invasive grayish-white mass in the right kidney and multiple nodules in the lungs, thoracic wall, and spleen. Histologically, the renal mass and the other nodules were mainly composed of papillotubular structures lined by oval-to-polygonal pleomorphic cells. The cells were reactive with DBA, PNA, and UEA-1 lectins and positive for vimentin but negative for CD10 and high molecular weight cytokeratin. Because of its histological, histochemical, and immunohistochemical similarities with human collecting duct carcinoma (CDC), a diagnosis of renal collecting duct carcinoma with pulmonary, thoracic, and splenic metastases was established. To our knowledge, this is the first case report of CDC in animals.

Key words: Collecting duct carcinoma (CDC); dogs; immunohistochemistry; kidney.

Request reprints from Dr. Y Nagashima, Department of Molecular Pathology, Yokohama City University Graduate School of Medicine, B252, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004 (Japan). E-mail: ynagas{at}med.yokohama-cu.ac.jp


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