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Vet Pathol 45:512-515 (2008)
© 2008 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Polycystic Ovary Syndrome with Endometrial Hyperplasia in a Cynomolgus Monkey (Macaca fascicularis)

E. Arifin, C. A. Shively, T. C. Register and J. M. Cline

Department of Pathology, Comparative Medicine Section, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC

Abstract

A 13-year-old, obese, female cynomolgus monkey (Macaca fascicularis) was observed in a 5-year neurobehavioral study and was humanely euthanatized for experimental purposes. During this observational study, the monkey was noted to ovulate only rarely (0–3 times a year), with a prolonged menstrual cycle length (up to 161 days), hyperandrogenism (androstenedione area under the curve in response to adrenocorticotropic hormone up to 27.64 ng/ml), and hyperinsulinemia (fasting insulin up to 65.85 µIU/ml). This animal's body mass index was 65.46 kg/m2, with central obesity. On postmortem examination, the uterus was moderately enlarged, with an eccentric lumen and a broad-based endometrial polyp that consisted of complex glandular hyperplasia with atypia. Both ovaries contained many 2- to 3-mm follicles, without any corpora lutea. A diagnosis of polycystic ovary syndrome was made based on the clinical history, endocrinology, and gross and histopathologic findings.

Key words: Cynomolgus monkey; endometrial hyperplasia; polycystic ovary syndrome.

Request reprints from Dr. J Mark Cline, Department of Pathology, Comparative Medicine Section, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1040 (USA). E-mail: jmcline{at}wfubmc.edu


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