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Vet Pathol 45:640-644 (2008)
© 2008 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Porcine Circovirus 2 Inclusion Bodies in Pulmonary and Renal Epithelial Cells

Y. Y. Huang, I. Walther, S. A. Martinson, A. López, C. Yason, D. L. Godson, E. G. Clark and E. Simko

Departments of Veterinary Pathology (YYH, ES) and Prairie Diagnostic Services (DLG), Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK; Department of Pathology and Microbiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PE (IW, SAM, AL, CY); and University of Calgary Faculty of Veterinary Medicine and Calgary Animal Referral and Emergency Centre, Calgary, AB (EGC), Canada

Abstract

Porcine circovirus 2 (PCV2) is the cause of postweaning multisystemic wasting syndrome (PMWS). The most common lesions of PMWS are lymphohistiocytic to granulomatous lymphadenitis, interstitial pneumonia and interstitial nephritis, with intracytoplasmic amphophilic botryoid inclusion bodies in macrophages. In addition to these typical changes, intracytoplasmic botryoid inclusion bodies were observed in bronchial, bronchial glandular, and renal tubular epithelium of several pigs from 4 different farms in Western and Eastern Canada. PCV2 inclusion bodies were demonstrated to be located in the cytoplasm of epithelial cells by immunohistochemical staining for PCV2 and cytokeratin antigens and by ultrastructural demonstration of viral particles in the inclusion bodies within renal tubular epithelium.

Key words: Intracytoplasmic epithelial inclusion bodies; porcine circovirus 2 (PCV2); postweaning multisystemic wasting syndrome (PMWS).

Request reprints from Elemir Simko, Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK, S7N 5B4, (Canada). E-mail: elemir.simko{at}usask.ca


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Copyright © 2008 by the American College of Veterinary Pathologists.