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Cervical Spinal Chordoma with Chondromatous Component in a Dog

Institute of Pathology and Forensic Veterinary Medicine (AG, AU), Department of Pathobiology, Clinic of Diagnostic Imaging (SK), and Clinic of Surgery and Ophthalmology (BV), Department for Small Animals and Horses, University of Veterinary Medicine, Vienna, Austria

Abstract

A 7-year-old male Belgian Shepherd dog was presented with sudden onset of lateral recumbency and tetraparesis. At the level of the third cervical vertebra, magnetic resonance imaging demonstrated an intrameningeal and intramedullary mass lesion. The animal was subsequently euthanatized. A necropsy revealed a semitranslucent solid mass infiltrating dorsal and ventral dura mater and the spinal cord. Histologic examination revealed a lobulated pleomorphic mass, mainly resembling undifferentiated cartilage interspersed by spindle-shaped and polygonal cells with highly vacuolated cytoplasm (physaliphorous cells). Immunohistochemistry of the tumor cells demonstrated dual expression of vimentin and cytokeratin. Based on the histologic and immunohistochemical results, the diagnosis of a chordoma with chondromatous component was made.

Key words: Chondroid chordoma; dogs; spinal cord; tumor.

Request reprints from A Gruber, Institute of Pathology and Forensic Veterinary Medicine, Department of Pathobiology, University of Veterinary Medicine Vienna, Veterinärplatz 1, A-1210 Wien (Austria). E-mail: andrea.gruber{at}vu-wien.ac.at