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Prostatic Squamous Metaplasia in a Cat with Interstitial Cell Neoplasia in a Retained Testis

Department of Pathobiology (ART); and Department of Small Animal Clinical Sciences (JRS), College of Veterinary Medicine, University of Tennessee, Knoxville, TN

Abstract

An 11-year-old cat with a retained testis was presented with a chronic history of dysuria and bladder atony. Medical therapy failed to alleviate the clinical signs. Contrast radiography demonstrated a diffusely narrowed urethra. During a celiotomy and prepubic urethrostomy, a retained testis, stenosed urethra, and irregularly enlarged prostate were observed. Histopathologic diagnosis was retained testis with a well-differentiated interstitial cell tumor, a poorly differentiated interstitial cell tumor, and marked squamous metaplasia of the prostatic epithelium with suppurative prostatitis. Neoplastic interstitial cells were immunoreactive for Melan A, consistent with reports of Melan A expression in steroid hormone-producing tissue. This is the first report of prostatic squamous metaplasia associated with testicular neoplasia in a felid.

Key words: Cats; dysuria; immunohistochemistry; interstitial cell tumor; Leydig cell tumor; prostate; testis.

Request reprints from Dr. A R Tucker, Rollins Laboratory, North Carolina Department of Agriculture, 2101 Blue Ridge Rd., Raleigh, NC 26706 (USA)

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