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Vet Pathol 46:59-62 (2009)
© 2009 American College of Veterinary Pathologists
INFECTIOUS DISEASE (RESEARCH)

Detection of Pathologic Prion Protein in the Olfactory Bulb of Natural and Experimental Bovine Spongiform Encephalopathy Affected Cattle in Great Britain

Y. H. Lee, M. M. Simmons, S. A. C. Hawkins, Y. I. Spencer, P. Webb, M. J. Stack and G. A. H. Wells

National Veterinary Research and Quarantine Service, Anyang, Republic of Korea (YHL), Veterinary Laboratories Agency, Addlestone, Surrey, United Kingdom (MMS, SACH, YIS, PW, MJS, GAHW)

Abstract

To investigate the relative involvement of the olfactory region in classical bovine spongiform encephalopathy (BSE), immunohistochemical labeling of prion protein scrapie (PrPSc) was scored in the brainstem, frontal cerebral cortex, and olfactory bulb of cattle with natural and experimental clinical cases of BSE in Great Britain. The intensity of immunolabeling was greatest in the brainstem, but PrPSc was also detected in the olfactory bulb and the cerebral cortex. A diffuse, nonparticulate labeling, possibly due to abundance of cellular PrP, was consistently observed in the olfactory glomeruli of the cases and negative controls. Involvement of the olfactory bulb in BSE and other naturally occurring TSEs of animals raises speculation as to an olfactory portal of infection or a route of excretion of the prion agent.

Key words: BSE; olfactory bulb; olfactory glomeruli; PrPSc; PrPC.

Request reprints from M M Simmons, Veterinary Laboratories Agency, Woodham Lane, New Haw, Addlestone, Surrey, KT15 3NB (UK). E-mail: m.m.simmons{at}vla.defra.gsi.gov.uk


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