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Maronpot, R. R., Boorman, G. A., and Gaul, B. W. (eds.) Pathology of the Mouse, 699 pp. Cache River Press, Vienna, IL, USA, 1999. $137.50. ISBN 1-889899-03-8.

This book is a comprehensive textbook on the morphologic pathology of the mouse, with particular emphasis on the B6C3F1 mouse. The book is organized by organs and organ systems. Each chapter is consistently organized, with discussion and documentation of normal embryology, anatomy, and histology; congenital lesions; degenerative lesions; inflammatory and vascular lesions; hyperplastic and neoplastic lesions; and miscellaneous lesions and toxicologic lesions. Each chapter also has a reference list. The concluding chapter provides NTP historical data on incidence of neoplasms in the B6C3F1 mouse.

The intended audience for this book are veterinary pathologists using the mouse in toxicologic pathology or research. The book is eminently readable, with each chapter clearly written and accurate descriptions of lesions. The book is copiously illustrated by high-quality photomicrographs, primarily of hemotoxylin and eosin–stained sections. For example, the chapter on the liver has 98 figures. Primary emphasis of the book is diagnoses on hemotoxylin and eosin–stained sections, with generally less emphasis on ancillary techniques, such as immunohistochemistry and special stains. Detailed subclassifications of neoplasms in certain organ systems are not always addressed, but references on this topic are provided in each chapter.

Pathology of the mouse will be of greatest use to the bench pathologist performing toxicologic pathology evaluations. Although the text emphasizes the B6C3F1 mouse, it will also serve as a useful reference for veterinary and experimental pathologists evaluating genetically engineered mice because of its extensive documentation background of lesions that are present not only in this hybrid but also in other strains and stocks. Scientists using mice in basic or applied research also will appreciate this reference.

This book will be an excellent addition to the library of any pathologist who performs pathology evaluations on mice.

Dr. M. R. Anver

SAIC Frederick
NCI-FCRDC
Frederick, MD

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