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Vet Pathol 41:302 (2004)
© 2004 American College of Veterinary Pathologists
Letter to the Editor

Editor:

After the publication of our article "Follicular stem cell carcinoma: histologic, immunohistochemical, ultrastructural, and clinical characterization in 30 dogs,"4 two colleagues have contributed helpful comments worthy of communication. Dr. S. M. Liu (IDEXX Veterinary Services) has identified recently a similar tumor in a cat, indicating that this tumor is not unique to the dog. Dr. B. A. Summers (Cornell University) indicated that this entity was described by Drs. Jabara and Finnie 25 years ago.3 These authors identified this tumor in four dogs and named it "clear-cell hidradenocarcinoma," now designated porocarcinoma in the human literature.5 Although Jabara and Finnie do not describe trichoepitheliomatous differentiation and pigmentation in their series of tumors, the descriptions and photomicrographs of their cases are strikingly similar to the tumors from our report. In our larger series of 30 cases, we found that most of these canine dermal carcinomas could undergo trichoepitheliomatous, apocrine, and outer root sheath differentiation, consistent with a tumor arising from a pluripotent cell. Choosing an appropriate name for these tumors is not an easy task, as shown by the endless controversies surrounding categorization schemes of dermal tumors with apocrine differentiation in humans.1,2,5 We feel that naming these tumors on the basis of apocrine differentiation alone is less satisfactory, given their ability to show divergent differentiation. Trichoepitheliomatous and outer root sheath differentiation as well as the absence of sebaceous differentiation argue against a diagnosis of adnexal stem cell carcinoma. Tumor nomenclature should be viewed as a work in progress, subject to change as knowledge expands.

I. Mikaelian

The Jackson Laboratory
600 Main Street
Bar Harbor, ME 04609f

V. Wong

California Primate Research Center
University of California
, Davis, CA 95616

References

  1. Cotton DW, Braye SG: Dermal cylindromas originate from the eccrine sweat gland. Br J Dermatol 111:53-61, 1984[Medline]
  2. Iyer PV, Leong AS: Malignant dermal cylindromas. Do they exist? A morphological and immunohistochemical study and review of the literature. Pathology 21:269-274, 1989[Medline]
  3. Jabara AG, Finnie JW: Four cases of clear-cell hidradenocarcinomas in the dog. J Comp Pathol 88:525-532, 1978[Medline]
  4. Mikaelian I, Wong V: Follicular stem cell carcinoma: histologic, immunohistochemical, ultrastructural, and clinical characterization in 30 dogs. Vet Pathol 40:433-444, 2003[Abstract/Free Full Text]
  5. Urso C, Bondi R, Paglierani M, Salvadori A, Anichini C, Giannini A: Carcinomas of sweat glands: report of 60 cases. Arch Pathol Lab Med 125:498-505, 2001[Medline]




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